Revital Amiaz a , Harrison G. Pope Jr. b , Thomas Mahne b , John F.
Kelly b , Brian P. Brennan b , Gen Kanayama b , Mark Weiser a , James
I. Hudson b & Stuart N. Seidman c
a The Chaim Sheba Medical Center, Tel Hashomer, Israel
b Biological Psychiatry Laboratory, McLean Hospital, Belmont,
Massachusetts, USA
c Columbia University College of Physicians & Surgeons, New York,
New York, USA
Available online: 27 Jun 2011
Testosterone replacement is the most effective treatment for sexual
dysfunction in hypogonadal men. Comorbid depression and
antidepressant side effects may reduce its influence. The authors
conducted a 6-week, double-blind, placebo-controlled clinical trial
of testosterone gel versus placebo gel in men with major depressive
disorder who were currently taking a serotonergic antidepressant
and exhibited low or low-normal testosterone level. A total of
100 men were enrolled at 2 study sites (Boston, Massachusetts,
USA, and Tel Aviv, Israel). The effects of testosterone augmentation
on sexual functioning were determined using domain scores
on the International Index of Erectile Function (IIEF). Complete
pre- and posttrial IIEF data were available for 63 subjects. Men...
